anti-PD-L1, anti-PD-L2, anti-CD137, or anti-CTLA-4 antibody, or any other antibody or drug specifically targeting T-cell co-stimulation or checkpoint pathways

Purified anti-human CD137 (4-1BB) Antibody CD137 is a 39 kD transmembrane protein also known as 4-1BB. It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor .

(2002) J Clin Invest 109, 651-9. 2019-10-02 · CD137, a member of the tumor necrosis factor receptor superfamily of cell surface proteins, acts as a costimulatory receptor on T cells, natural killer cells, B cell subsets, and some dendritic cells. Agonistic anti-CD137 monoclonal antibody (mAb) therapy has been combined with other chemotherapeutic agents in human cancer trials. Biotin anti-human CD137 (4-1BB) Antibody - CDw137 is a 39 kD transmembrane protein also known as 4-1BB. Anti-CD137 antibody produced in goat is suitable for capture ELISA, western blot, immunocytochemistry, flow cytometry CD137 is a 39 kD transmembrane protein also known as 4-1BB. It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily.

Cd137 antibody

Targeting CD137 or its ligand (CD137L) has been studied, aiming to enhance anticancer immune responses. Urelumab (BMS-663513 or anti-4-1BB antibody) is a fully human IgG4 monoclonal antibody developed by Bristol-Myers Squibb for the treatment of cancer and solid tumors. Urelumab targets the extracellular domain of CD137. CD137 (4-1BB) is a member of the TNFR superfamily that represents a promising target for cancer immunotherapy.

One study demonstrated CD137 antibody positive IHC staining in a majority of Classical Hodgkin Lymphoma (CHL) tissues, indicating its usefulness as a diagnostic biomarker for CHL. CD137/TNFRSF9 was also found to be a highly specific immunohistochemical marker of …

Custom antibody services and bulk production also available. To learn more comprehensive our antibody product information including immunogen, specificity, and more, you can read all details here.

24 Feb 2011 Abstract. Antibody-dependent cell-mediated cytotoxicity (ADCC), which is largely mediated by natural killer (NK) cells, is thought to play an important role in.

Interaction of CD137 with its ligand, 4-1BBL (CD137L), is important in T-B cell costimulation. The 17B5 antibody has been reported to block 4-1BBL costimulated T cell proliferation. Product Details Rabbit polyclonal CD137 antibody. Validated in IHC and tested in Human. Cited in 2 publication(s). Independently reviewed in 1 review(s).

Accumulating evidence suggests that anti-CD137 antibodies can be used separately to prevent tumor in some cases, while in other cases, these antibodies need to be co-administered with other antibodies or drugs/vaccines/regents for a better performance. CD137 is a 39 kD transmembrane protein also known as 4-1BB. It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily. CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand.
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Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD137 antibody (ab203391) Immunohistochemical analysis of formalin-fixed paraffin-embedded rat brain tissue, labeling CD137 using ab203391 at a 1/600 dilution, followed by conjugation to the secondary antibody and DAB staining. In the past 5 years, immunomodulatory antibodies have revolutionized cancer immunotherapy. CD137, a member of the tumor necrosis factor receptor superfamily, represents a promising target for enhancing antitumor immune responses. CD137 helps regulate the activation of many immune cells, including CD4+ T cells, CD8+ T cells, dendritic cells, and natural killer cells.

Supplied as 100 Tests purified antibody (5 µL/Test).
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eller K562-celler dubbelomvandlade med IL-15 och 4-1BB (CD137) -ligand (K562 NK cell effector functions can also be mediated by antibody-dependent

Independently reviewed in 1 review(s). Immunogen corresponding to fusion protein. 798 products Anti-CD137 Antibody Products.

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CD137 is mainly expressed on activated CD4+ and CD8+ T cells, activated B cells, and natural killer cells, but can also be found on resting monocytes and dendritic cells.As a costimulatory molecule it is involved in the activation and survival of CD4+ or CD8+ T cells, and NK cells.

The CD137 molecule is primarily expressed on ac… Purified anti-human CD137 (4-1BB) Antibody CD137 is a 39 kD transmembrane protein also known as 4-1BB. It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor .