(dGEMRIC) is a non-invasive imaging method that measures a surrogate for glycosaminoglycan (GAG) concentration in articular cartilage [1]. GAG is a macromolecule whose con-

Hence, the dGEMRIC technique holds promise for the development of new diagnostic and therapeutic procedures. However, because of the location of the hip joint deep within the body and due to the fairly thin cartilage layers that require high spatial resolution, the diagnosis of early hip joint cartilage alterations may be problematic.

The most straightforward application of dGEMRIC or any molecular imaging technique is simply to demonstrate and follow “lesions” in otherwise apparently normal-appearing cartilage. Detection and monitoring of these lesions demonstrate a number of paradigm-changing concepts in the evaluation of cartilage physiology and pathophysiology. The dGEMRIC technique is based on the electrical polarity of gadolinium [Gd (DPTA)2− ions] and glycosaminoglycans in the joint. (dGEMRIC) has been shown to be a clinically useful tool for assessing the glycosaminoglycan (GAG) content in cartilage (1–4).

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Hence, the dGEMRIC technique holds promise for the development of … Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) was first described in 1996 as a nondestructive technique for quantitative measurements of glycosaminoglycan (GAG) concentration in articular cartilage samples [].Its translation to clinical platforms as a means of interrogating the molecular aspects of cartilage was demonstrated in 1997 with illustrative examples of apparent … 2012-10-01 (dGEMRIC) is a non-invasive imaging method that measures a surrogate for glycosaminoglycan (GAG) concentration in articular cartilage [1]. GAG is a macromolecule whose con- Background: Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) is a validated technique for evaluating cartilage health in developmental dysplasia of the hip (DDH), which can be a helpful prognosticator for the response to surgical treatments. dGEMRIC requires intravenous injection of gadolinium contrast, however, which adds time, expense, and 2013-07-01 2013-12-20 Purpose: To determine the feasibility of using a high resolution isotropic three-dimensional (3D) fast T1 mapping sequence for delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) to assess osteoarthritis in the hip. The delayed Gadolinium Enhanced Magnetic Resonance Imaging of Cartilage (dGEMRIC) technique is a well- established method for early assessment of cartilage quality in osteoarthritis. Using this technique, the distribution of Gd-(DTPA)2−contrast agent in cartilage after intravenous injection is assessed with quantitative T1 2018-05-16 Current knowledge and importance of dGEMRIC techniques in diagnosis of hip joint diseases Zilkens, Christoph; Tiderius, Carl Johan LU; Krauspe, Ruediger and Bittersohl, Bernd () In Skeletal Radiology 44 (8).

Hence, the dGEMRIC technique holds promise for the development of new diagnostic and therapeutic procedures. However, because of the location of the hip joint deep within the body and due to the fairly thin cartilage layers that require high spatial resolution, the diagnosis of early hip joint cartilage alterations may be problematic.

Optimization of a 3D Phase-Sensitive IR protocol for DGEMRIC technique. M. Durkan1, J. Szumowski2, D. Brown1, D. Crawford1, E. Schwarz2, and K. Heiles3 1Orthopaedics To determine the feasibility of using a high resolution isotropic three‐dimensional (3D) fast T1 mapping sequence for delayed gadolinium‐enhanced MRI of cartilage (dGEMRIC) to assess osteoarthritis in Since our knowledge of both the measurement properties of these imaging techniques, and the in-vivo efficacy of CH, is insufficient to design a definitive clinical trial, we performed a pilot study to determine if dGEMRIC and T2 mapping can discriminate changes in knee hyaline cartilage among participants taking a CH preparation (Fortigel ®) compared to those taking placebo. Abstract.

Abstract. Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) is a new technique to study cartilage glycosaminoglycan (GAG) content. The negatively charged contrast agent Gd-DTPA2-, injected intravenously, distributes in the cartilage inversely to the likewise negatively charged GAG.

Compositional assessment techniques include T2 mapping, delayed gadolinium-enhanced MR imaging of cartilage (dGEMRIC), T1ρ imaging, sodium imaging, and diffusion-weighted imaging. Techniques used to assess proteoglycan content and distribution include sodium-23 imaging, delayed gadolinium-enhanced MR imaging of cartilage (dGEMRIC), and T1rho (>)-weighted MR imaging.

Outcomes of dGEMRIC, however, did not change after Viscosupplementation, indicating no change in cartilage p-values adjusted using Holm's method <0.05 .
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av M AHLDÉN · Citerat av 1 — cartilage (dGEMRIC).

Objective: Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) reflects cartilage In the dGEMRIC technique, the negatively charged con-.
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(dGEMRIC) has been shown to be a clinically useful tool for assessing the glycosaminoglycan (GAG) content in cartilage (1–4). Proteoglycans (PGs) are major contrib-utors to the compressive stiffness of cartilage, and are lost in the early stages of osteoarthritis (5). The dGEM-RIC technique measures the T1 relaxation time of car-

The method is robust, but requires injection of contrast agent and a cumbersome examination procedure.